A Transplantable Induced Melanotic Tumor of the Syrian Golden Hamster*
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چکیده
The present paper records the availability of a new transplantable melanotic tumor in the Syrian golden hamster. A previous report (1) described the induction of multiple pigmented tumors in the Syrian golden hamster following the application to the skin of a single dose of the carcinogen 9,10dimethyl-l,2-benzanthracene. These tumors were sharply demarcated and located in the dermis and subcutaneous tissues. Histologically, they were predominantly composed of spindle-shaped cells containing large amounts of melanin in the cytoplasm. No métastaseswere seen even when tumors reached a size of more than 4 cm. in diameter. In the initial study, a footnote recorded the successful transplantation of one of these tu mors. This report records further transplantation studies and the characteristics of the transplanted tumors.
منابع مشابه
A transplantable induced melanotic tumor of the Syrian golden hamster.
The present paper records the availability of a new transplantable melanotic tumor in the Syrian golden hamster. A previous report (1) described the induction of multiple pigmented tumors in the Syrian golden hamster following the application to the skin of a single dose of the carcinogen 9,10dimethyl-l,2-benzanthracene. These tumors were sharply demarcated and located in the dermis and subcuta...
متن کاملStudies of Skin Carcinogenesis in the Syrian Golden Hamster*
The carcinogens 9,10-dime thy 1-1,2-benzanthracene, 20-methylcholanthrene, 3,4benzpyrene, 1,2,5,6-dibenzanthracene, 1,2-benzanthracene, and 2-anthramine have been tested topically in the Syrian golden hamster. The mouse skin tumor-promoting agents, croton oil and polyoxyethylene sorbitan monostearate (Tween 60), have been tested on hamster skin following a single applica tion of 9,10-dimethyl-l...
متن کاملThe Induction of Melanotic Tumors Resembling Cellular Blue Nevi in the Syrian White Hamster by Cutaneous Application of 7,12-Dimethylbenz[a]anthracene*
Melanotic tumors resembling cellular blue nevi of man were induced in the Syrian white hamster by single and multiple applications of 7,1~-dimethylbenz[a]anthracene (DMBA). Histologically they resembled the melanotic tumors produced under similar experimental conditions in the Syrian golden hamster. They showed great variations in pigment content from almost nonpigmented to heavily pigmented tu...
متن کاملStudies of skin carcinogenesis in the Syrian golden hamster.
The carcinogens 9,10-dime thy 1-1,2-benzanthracene, 20-methylcholanthrene, 3,4benzpyrene, 1,2,5,6-dibenzanthracene, 1,2-benzanthracene, and 2-anthramine have been tested topically in the Syrian golden hamster. The mouse skin tumor-promoting agents, croton oil and polyoxyethylene sorbitan monostearate (Tween 60), have been tested on hamster skin following a single applica tion of 9,10-dimethyl-l...
متن کاملStudies on transplantation and behavior of hamster melanoma.
The first report of a methylcholanthrene-in duced transplantable melanotic tumor in a Syrian golden hamster was published by Shubik and asso ciates (14). Spontaneous hamster melanomas have been reported by Fortner and Allen (1) and Greene (5). Shubik found that no metastases occurred even when the tumors attained a size of 4 cm. in diameter. Fortner and Allen, and Greene reported diffuse metast...
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